The M3DiCam project aims to use miniaturized gamma cameras for visualization and discrimination of radiolabeled target tissues from surrounding structures, enhancing surgical precision and safety especially in oncological interventions. Miniature gamma cameras based on semiconductor detectors will be optimized for integration into an endoscope, corresponding software development will enable integration of multiple moving sensors. Performance will be validated by ex-vivo experiments.
The optimized and miniaturized gamma imaging system uses principle of Compton camera. The integration of miniaturized Compton imagers into surgical platforms presents significant potential for transforming the healthcare delivery. Clinically, these imagers offer transformative benefits by revolutionizing intra-operative imaging. Their real-time, high-resolution capability enables precise localization of tumors and critical anatomical structures labeled by radioactive tracers. This is crucial for achieving complete tumor resection while minimizing damage to healthy tissue. By enhancing accuracy, Compton imagers reduce the risk of complications, shorten surgical times, and enhance overall patient safety. Moreover, their omnidirectional nature streamlines the imaging process, enhancing workflow efficiency without the constraints of traditional gamma cameras. Seamlessly integrated with device tracked and robotic platforms, Compton imagers ensure compatibility and ease of use for surgical teams.
The current method of utilization of a-priori SPECT/CT for the planning of oncological interventions represents a critical advancement in preoperative assessment and strategy formulation. By integrating single-photon emission computed tomography (SPECT) with computed tomography (CT) imaging, clinicians can obtain detailed anatomical and functional information about tumors and surrounding tissues, enhancing the precision and efficacy of oncological interventions.
Addressing the problem of patient positioning mismatch and anatomical deformation in this context is paramount. Despite meticulous planning based on preoperative imaging, patient positioning mismatches and anatomical deformations can occur during the actual surgical procedure, potentially leading to inaccuracies in tumor localization and resection margins. To mitigate these challenges, advanced techniques such as intraoperative imaging, image registration, and navigation systems can be employed.
The utilization of the Compton imager in oncological surgery offers distinct advantages. It’s compact size and lightweight design facilitate their integration into surgical platforms, allowing for close proximity, or even endoscopic placement, during surgical procedures. This proximity to the imaging target significantly enhances dose efficiency in radionuclide imaging, as the received signal increases quadratically with decreasing distance between the labeled lesions and the detector. Moreover, the reduced distance mitigates the impact of angular errors, making the angular precision of such cameras less critical as the distance decreases. This property is particularly advantageous for robotic surgery, where precise localization of targets is crucial for accurate interventions